CRRT vs CRRT+PLEX in Acute Liver Failure: Pilot Study Outcomes & Multicentric Study Proposal
Ethical Clearance
Not Applied
Study Status
Not Yet Recruiting
Investigating Team
Dr. Radhika Ruhatiya, Dr. G. Chaubal, Dr. U Sanglodkar, Dr. A. Chaubal, Dr.H Shah, Dr.A. Nanavati,Dr. H Hatimi,Dr. A Pakkala, Dr.S. Shah; Nanavati Max Super Speciality Hospital, Mumbai
Study Design
Study Design- Multicentric, Observational, Propensity-Matched Cohort Study
Study Interventions
• Group 1 (CRRT Alone)- Continuous veno-venous hemodiafiltration (CVVHDF) or hemodialysis (CVVHD) based on institutional protocols.
• Group 2 (CRRT + PLEX): CRRT as above + Plasma Exchange (PLEX) based on clinician decision.
Primary Outcome
To assess overall survival benefit of CRRT + PLEX vs. CRRT alone in ALF in patients who undergo or do not undergo liver transplant.
Secondary Outcome
1. Survival to liver transplant in both groups.
2. Transplant-free survival at 28, 60, and 90 days.
3. Overall survival at 28, 60, and 90 days post-enrollment.
4. Impact on organ failure resolution (SOFA, CLIF-C scores).
5. Renal function recovery (dialysis-free days, creatinine trajectory).
6. ICU and hospital length of stay.